Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine.
Cryptococcus neoformans is an opportunistic fungal pathogen that causes fatal meningoencephalitis in immunocompromised hosts such as patients with AIDS and hematological malignancy. Host defense to C. neoformansinfection is mediated by Th1-type cellular immunity, which is triggered by host cell recognition of the pathogen-associated molecular patterns via the pattern recognition receptors. Recently, our study revealed that TLR9-dependent sensing of cryptococcal DNA was a pivotal step in initiating the host defense to this infection and raised a possibility that this process may be triggered in a distinct manner by bacterial DNA with a canonical CpG motif. In addition, we found that mice deficient in CARD9, a critical adapter molecule for signaling via C-type lectin receptors (CLRs), was highly susceptible to cryptococcal infection with impaired immune responses, suggesting a possible involvement of some CLRs. In this article, we review advances in understanding the pattern recognition and host defense response to C. neoformans, with a particular focus on our recent results.
Am old enough to understand the difference between the Bay of Pigs - and roasting a pig at a epicurian feast. Been thru the hippy, yippie and yuppie years - always remaining who I am.
Very much believe in "Sing your own song - weave your own tapestry"
Am young enough to still know the thrill of new discoveries, the beauty of the evening, to celebrate the joy of another tommorow.
Survived these many decades with a severe medical problems. Sorting out the maze of now having two lymphomas and all their nasty little companions, but I continue.
Besides, being a simple iconoclastic eclectic, have been called many things. An incurable romanticist - with a strong touch of reality. Thinker, intellectual (God, how I hate that term) - been told I am a lion with the heart of the poet.
Know how to wage war and conquer my foes - but would rather be known as one who brings hope and life. To bring hope into anothers life is the ultimate of joys.
Life should be about bringing hope, peace, vision... a sense of purpose beyond yourself.